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Welcome to Our Blog

Explore expert insights on hormone therapy and integrative psychiatry to help you navigate this transition with confidence and ease.

Agnes Simone Agnes Simone

Estrogen and Mental Health: How Hormones Affect Mood, Anxiety, and Brain Function

Estrogen is both a reproductive hormone and a neuroactive hormone. It crosses the blood-brain barrier, binds to receptors throughout the brain, and regulates the neurotransmitter systems responsible for mood, anxiety, motivation, and cognition. When estrogen levels are stable, these systems function efficiently. When estrogen fluctuates or declines — across the menstrual cycle, postpartum, and during perimenopause — the mental health effects can be profound.

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Agnes Simone Agnes Simone

Health Is Wealth: What Thousands of Patients Taught Me About What Really Matters

Here's what I've come to believe: health isn't just one part of a good life. It's the part that makes everything else possible. You can work hard, build a career, create financial security for your family — and all of that matters. But if your body is worn down or your mind is struggling, none of those things feel the way you hoped they would.

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Agnes Simone Agnes Simone

Perimenopause and Mental Health: What’s Hormonal vs. What’s Not

Perimenopause, the transitional phase leading up to menopause, can begin in the mid-30s to early 40s and last for several years. During this time, estrogen and progesterone levels don’t just decline — they fluctuate unpredictably. Those fluctuations affect mood, sleep, focus, and emotional resilience in ways that are real, measurable, and too often missed.

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Dr. Agnes K. Simone Dr. Agnes K. Simone

Maybe It’s Not “Just PMS”

Snapping at loved ones, feeling hopeless before your period, then suddenly “back to normal”? It might not be just PMS. Learn how to recognize the signs of PMDD—and why getting the right support can be life-changing.

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Dr. Agnes K. Simone Dr. Agnes K. Simone

What Postpartum Care Planning With a Psychiatrist Looks Like

Welcoming a new baby is one of the most meaningful transitions in someone’s life, but it is also a time of major physical, emotional, and hormonal change. I never want new parents to enter the postpartum period feeling alone, overwhelmed, or unsure of what to expect. This is why I walk all my expecting moms and dads through a postpartum care plan well before delivery.

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Dr. Agnes K. Simone Dr. Agnes K. Simone

Progesterone and the Patterns of Women’s Health

Progesterone is often described as a “reproductive hormone,” but its role in the body goes far beyond fertility and pregnancy. Progesterone affects menstrual cycles, mood, sleep, brain function, and overall well-being, and changes in progesterone levels can have real physical and emotional effects throughout a woman’s life.

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Dr. Agnes K. Simone Dr. Agnes K. Simone

Why ADHD Is Missed in High-Functioning Women

Adult ADHD in women is frequently missed, delayed, or misattributed, especially in those who appear high functioning. Understanding why can be deeply validating and can open the door to more accurate diagnosis and effective treatment.

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Modern, Integrative, Hormone-Informed Psychiatric Care
for Midlife and Beyond

Schedule an appointment for psychiatric and hormonal care designed for women in midlife.